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Multimedia Muse treats visual stories in a way that makes good sense to me. This is a “show me” site, not a bang-bang-bang headlines site. This is a buffet spread out for you when you have 15 or 20 minutes to spare. Make it your lunch date today or tomorrow, and feast on some fine [...]
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Van Mon: A Forgotten Existence is a multimedia story reported and produced by Ehrin Macksey. I met Ehrin when he visited Florida last year; he lives in Hanoi, Vietnam, and makes his living there as a photographer and multimedia trainer. When I visited Vietnam in June, he was just trying out his new video camera, [...]
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There’s more to this brave new world of journalism than technology skills. Business sense will play a large role in the rest of your career, whether you are a journalism student or a seasoned veteran. If journalism students graduate without an understanding of how editorial, business, and technology work together, “you have not prepared them [...]
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I get excited when my RSS reader tells me Colin Mulvany, of The Spokesman-Review newspaper in Spokane, Washington, has put up a new blog post. Colin has taught me a lot about visual storytelling through his online work and his blogs. This new post is particularly good, because he tackles the quality vs. quantity debate [...]
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USA Today video journalist Garrett Hubbard will answer questions about visual storytelling in a live chat at 3:45 p.m. EDT on Thursday, Sept. 25, on Chrys Wu’s blog, Ricochet. I wrote about Hubbard’s outstanding video work last week.
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The best first step for a print reporter toward multimedia is audio. You already know how to conduct an interview, so you’re more than halfway there. Now all you need is some decent audio gathering gear and Audacity, a free audio editor that works on both Windows and Macs. All the information you need is [...]
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I updated my blogroll this morning. It needed some culling, as some blogs I used to read are no longer being updated. I added a few new ones too. Not necessarily new blogs, but new to my list. Yesterday I got a question from an audience of journalists: How can we find these blogs about [...]
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These drugs, called selective phodiesterase type 5 (PDE5) inhibitors, treat erectile dysfunction by interfering with the action of the compound PDE5 in the blood vessels of the penis. But there are concerns that PDE5 inhibitors may also act on similar compounds in the retina, the part of the eye that receives and transmits images to the brain, according to background information in the study.
Could Chinese Herb Be a Natural Viagra?
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How often are male factors involved?
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OBJECTIVE: Depressed men commonly have erectile dysfunction, and men with erectile dysfunction are frequently depressed. Since the etiologic and modulatory relationships between depression and erectile dysfunction have been poorly characterized, a 12-week, randomized, double-blind, placebo-controlled trial was conducted at 20 urologic clinics to evaluate the effects of sildenafil treatment in men with erectile dysfunction and mild-to-moderate comorbid depressive illness. METHOD: Men (N=152, mean age=56 years) with erectile dysfunction for =" src="/math/ge.gif"6 months (mean=5.7 years), a DSM-IV diagnosis of depressive disorder not otherwise specified, and a Hamilton Depression Rating Scale score =" src="/math/ge.gif"12 (mean at baseline=16.9) were randomly assigned to flexible-dose treatment with sildenafil citrate or matching placebo. Interviewer-rated and self-report instruments were used to assess changes in sexual function, depressive symptoms, and quality of life. Conservative criteria were used to classify erectile dysfunction treatment response and nonresponse. RESULTS: Sildenafil was strongly associated with erectile dysfunction treatment response. Fifty-eight men met the conservative criteria for response (48 given sildenafil, 10 given placebo), and 78 men did not respond (18 given sildenafil, 60 given placebo). Mean decreases of 10.6 and 2.3 in Hamilton depression scale scores were seen in treatment responders and nonresponders, respectively; 76% of treatment responders showed a =" src="/math/ge.gif"50% decline in Hamilton depression scale score versus 14% of nonresponders. Quality of life was similarly improved in treatment responders. CONCLUSIONS: Sildenafil is efficacious for erectile dysfunction in men with mild-to-moderate depressive illness. Improvement of erectile dysfunction is associated with marked improvement in depressive symptoms and quality of life.
Blood hormone studies: Testosterone and/or prolactin levels in the blood may be measured to see if abnormalities in either of these sex hormones are present.
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Penile Injection Therapy Backgrounder - Penile injection therapy was discovered fortuitously. In 1980, the French physician Ronald Virag reported that during penile surgery, he inadvertently injected an anesthetized patient in the wrong part of the penis with papaverine - a substance derived from the opium poppy. The resulting relaxation of the smooth muscle of the penile arterial walls created an unexpected two-hour erection. This mistake prompted serious research into the use of injectable medications to relieve ED. Around the same time, Giles Brindley, a British physiologist and research scientist, discovered that injecting the drug phenoxybenzamine into the corpora cavernosa of the penis could produce an erection within minutes. At a meeting in Paris in 1984, New York urologist Dr. Adrian Zorgniotti presented his first case studies of self-injection utilizing a combination of papaverine and phentolamine. The latter drug blocks the action of neurotransmitters that cause vasoconstriction, causing the smooth muscles of the penis to relax. Two years later, Japanese researchers presented evidence that injecting the drug prostaglandin E-1 produced powerful erections. Slowly, news of the favorable results with the injectable medication began to spread within the small international community of urologists who were treating ED. Most began utilizing all three (papaverine, phentolamine, and prostaglandin E-1) in what was referred to as "trimix."
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Duplex ultrasound is used to evaluate blood flow, venous leak, signs of atherosclerosis, and scarring or calcification of erectile tissue. Injecting prostaglandin, a hormone-like stimulator produced in the body, induces erection. Ultrasound is then used to see vascular dilation and measure penile blood pressure. Measurements are compared to those taken when the penis is flaccid.
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Erectile Dysfunction: Talking to Your Partner
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Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate the cellular levels of the second messengers, cAMP and cGMP, by controlling their rates of degradation. There are 11 different PDE families, with each family typically having several different isoforms and splice variants. These unique PDEs differ in their three-dimensional structure, kinetic properties, modes of regulation, intracellular localization, cellular expression, and inhibitor sensitivities. Current data suggest that individual isozymes modulate distinct regulatory pathways in the cell. These properties therefore offer the opportunity for selectively targeting specific PDEs for treatment of specific disease states. The feasibility of these enzymes as drug targets is exemplified by the commercial and clinical successes of the erectile dysfunction drugs, sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra). PDE inhibitors are also currently available or in development for treatment of a variety of other pathological conditions. In this review the basic biochemical properties, cellular regulation, expression patterns, and physiological functions of the different PDE isoforms will be discussed. How these properties relate to the current and future development of PDE inhibitors as pharmacological agents is especially considered. PDEs hold great promise as drug targets and recent research advances make this an exciting time for the field of PDE research.
Participate in common interests: Hobbies, sporting activities, or volunteer activities can bring couples closer together when they share interests.