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So you walk into someone’s home or workplace and do an interview. After you’ve finished taking notes, you whip out your iPod Nano and do a 2-minute video interview for the Web. This iPod is so small, you might lose it inside your pocket!
To test whether this new Nano (released last week) would produce usable video interviews, I tried it out with 10 of my colleagues in the College of Journalism and Communications. I wanted to keep the editing to a bare minimum, so I told each of them this: Name a place you have visited, when you went there, and one thing you did there. You’ll see and hear the different lighting conditions and sound quality.
I’ve been especially impressed by the audio, which is omnidirectional. I’m not wild about the image quality. My Canon PowerShot (still camera) does a better job with the visuals.
The biggest problems I had were stopping the recording (it does not want to stop!) and keeping the Nano steady. I’m pretty well practiced at keeping a little Canon PowerShot steady, but this was a lot harder. Let me know if you think it’s too shaky.
Here’s the for this Nano — “H.264 VGA video, 640 by 480 pixels, up to 30 frames per second with AAC audio.” There are two models: 8 GB and 16 GB. Video capture runs at about 18 MB per minute. Battery life seems good so far.
The user’s manual for the Nano is online (; 2 MB).
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Supplements are intended to provide nutritional support. Because a supplement or a recommended dose may not be appropriate for all persons, a physician (i.e., a licensed naturopathic physician or holistic MD or DO) should be consulted before using any product.
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Research into the structure, function, and regulation of PDEs has progressed a long way from the initial identification of PDE activity nearly 50 years ago. The PDE enzymes are now well recognized to be important regulators of many different cellular functions. Research in the field has evolved from early studies primarily concerning identification of PDE enzymes and characterization of their kinetic and regulatory properties to more recent work on their structure and how their activities are regulated in the cellular context. This accumulation of basic knowledge should further foster the targeting of these enzymes for drug development and clinical treatment.
Reviewed by Brunilda Nazario, MD
The dual specificity cGMP-binding PDE. The four PDE11A variants differ largely in how many and how complete their GAF domains are. The significance of the PDE11 phosphorylation sites is unknown.
The PDE11A gene occupies >300 kb of genomic DNA and contains 23 exons of generally small size. The four PDE11A variants have different amino termini due to separate transcriptional start sites (Hetman et al., 2000a; Yuasa et al., 2000). Only PDE11A4 contains two complete GAF domains. Oddly enough, the separate transcriptional start sites for PDE11A1-3 result in production of proteins with incomplete GAF domains (Hetman et al., 2000). PDE11A1 completely lacks the N-terminal-most GAF domain, but contains the complete second GAF domain. PDE11A3 and PDE11A2 have one complete GAF domain and one partial GAF domain. The functional consequence(s) of these truncations is unknown, but the truncations do seem to affect catalytic activity.
Learning to overcome ED is like learning any sexual skill; it takes patience, practice, and a partner. Solving erection problems is only a part of regaining a satisfying sex life. You and your partner have a whole world of erotic possibilities to explore. Remember the sexiest word in the language: communication.
Topical Erectile Dysfunction Therapy Shows Promise
Under the current Government guidelines, only 47.6% of men with ED are eligible for treatment under the NHS (see Table 1). Out of the 147, 58 patients (40%) had one or more cardiovascular risk factors (hypertension, ischaemic heart disease, arrrythmia, congestive heart failure, dyslipidaemia or peripheral vascular disease). Only 32 of these patients (i.e. 55% of those with CVS risk factors) qualified for NHS treatment based on other grounds.
Smoking cigarettes doubles the risk of erectile dysfunction.
Men taking the protease inhibitor (for the treatment of HIV/AIDS) indinavir (Crixivan ) should not take more than 2.5 mg of vardenafil in a 24-hour period.
The birth control patch, or Ortho EvraŽ, is a slim patch you apply once a week for three weeks at a time. When used correctly it is as effective as the birth control pill, with a failure rate less than one percent. However, it may not be as effective for women who are over 198 pounds, so they should use it in combination with condoms to avoid pregnancy, warns ACOG.
Radical cystectomy (for bladder cancer) and prostatectomy (for prostate cancer) require cutting or removing nerves that control penile blood flow. These nerves do not control sensation in the penis and are not responsible for orgasms; only erection is affected by these procedures.
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These are generally ineffective when tested blind, but may be useful for their psychological (placebo) effect: if a good result is expected, any highly-praised, and often expensive, treatment can be effective. Reputable drugs can also benefit from the same effect.
For example, television advertisements for Cialis, Levitra and Viagra have changed the perception of what it is to be a normal, healthy man, Metzl said. In that way, male sexual performance has been "medicalized."
If impotence is related to a treatable medical condition, will ED symptoms resolve with successful treatment for the underlying disorder?
How is erection sustained?
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