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In June I posted a ranked list of skills needed by todayâ€™s journalists. In reviewing it today, I wondered whether it would be different if instead of saying journalist we said reporter. Say you want to hire a reporter — for a Web-only organization, a magazine, a newspaper, a TV or documentary outfit. Or for [...]
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Here’s a new, stripped-down, easy-to-follow introduction to WordPress — the free blogging platform that also works as a versatile content management system: WordPress Basics This short tutorial is based on the second installment in my Reporter’s Guide to Multimedia Proficiency, but I have shortened it to the essentials so that I can just give it [...]
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Possibly uncomfortable ejaculation
The physical examination can reveal clues for physical causes of erectile dysfunction. For example, if the penis does not respond as expected to touching, a problem in the nervous system may be the cause. Small testicles, lack of facial hair and enlarged breasts can point to hormonal problems such as hypogonadism with low testosterone levels. A reduced flow of blood as a result of atherosclerosis can sometimes be diagnosed by finding diminished arterial pulses in the legs or listening with a stethoscope for bruits (the sound of blood flowing through narrowed arteries). Unusual characteristics of the penis itself could suggest the root of the erectile dysfunction, for example, bending of the penis during erection could be the result of Peyronie's disease.
Not in most cases. Rarely, premature ejaculation results from a serious health problem, such as nervous system damage from surgery or trauma.
This is the first demonstration that PDE5 blockade exerts an indirect, immune-mediated, antineoplastic effect through inhibition of MDSC-mediated immunosuppressive mechanisms. These findings could establish a new role for PDE5 inhibition as a viable and effective immunological adjunct in the treatment of various malignancies, thereby adding to the growing list of therapeutic applications of these agents. In this paper we show that PDE5 inhibition can significantly overcome the immunosuppressive mechanisms present in a tumor-bearing host to generate immune responses that are similar to (if not greater than) those observed in a non– tumor-bearing, vaccine-primed host (Fig. 2). However, although a CTL response can be elicited, PDE5 blockade is incapable of complete tumor eradication (Fig. S1). Several hypotheses may account for these findings. For example, chronic sildenafil blockade may up-regulate PDE5 expression, making it difficult to achieve complete and long-term pharmacologic inhibition (39). Alternatively, the sildenafil-mediated immune response against the self tumor-associated antigen can predominantly involve low affinity CD8+ T cells incapable of complete tumor cell killing. Finally, the tumor-specific immune response may ultimately result in immune editing of the tumor that escapes immune recognition (Fig. S1, C and D).
Several laboratory tests can help diagnose ED. Tests for systemic diseases include blood counts, urinalysis, lipid profile, and measurements of creatinine and liver enzymes. Measuring the amount of free testosterone in the blood can yield information about problems with the endocrine system and is indicated especially in patients with decreased sexual desire.
STUDY SELECTION AND DATA EXTRACTION: All identified research, review articles, and abstracts were assessed for relevance, and all relevant information was included. Priority was given to the primary medical literature and clinical trial reports.
What precautions should be taken when using tadalafil?
"This is the time to treat your man as your best friend -- to be warm, to be friendly, to grab his hand, to give him hugs and kisses, to let him know that you care about him, that he is desirable, that physical closeness is important," says Foley.
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The research comes as government agencies debate the safety of BPA, a compound that is found in thousands of consumer products ranging from dental sealants to canned food linings and that is so ubiquitous it has been detected in the urine of 93 percent of the U.S. population.
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ScienceDaily (Jan. 2, 2010) — A study in the Jan. 1 issue of the journal Sleep shows that erectile dysfunction was more common in older men with restless leg syndrome (RLS) than in those without RLS, and the magnitude of this association increased with a higher frequency of RLS symptoms.
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Excessive alcohol use has long been recognised as one cause of impotence, leading to the euphemism "brewer's droop"; Shakespeare made light of this phenomenon in Macbeth.
But what was it about cycling that led particularly to erectile dysfunction? Goldstein's study hadn't uncovered a cause, but another study done at the University of California, San Diego, offered an explanation. The study -- done in conjunction with Serfas, a bicycle accessory company in Lake Forest, Calif. -- found that the rub lies not in cycling itself but in the seats.
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Identical to naturally occurring PGE1 and has various pharmacologic effects, including vasodilation and inhibition of platelet aggregation. When injected into the penile shaft, it relaxes trabecular smooth muscle, dilating cavernosal arteries, which, in, turn promotes blood flow and entrapment in the lacunar spaces of the penis, causing penile erection. Various doses have been used.
Tadalafil has been shown to improve endothelial function in men with ED. Rosano et al studied brachial artery blood flow in 32 men with increased cardiovascular risk factors.6 They found that blood flow was significantly improved and this benefit remained for 2 weeks after cessation of the medication.
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