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Having survived two weeks’ absence from my RSS feeds (vacation!), I have a lot of catching up to do. These three posts from Andy Dickinson are at the top of my list. How the broadsheets use video: The Telegraph Financial Times The Guardian Then there’s a New York Times feature from last Sunday. Let me [...]
People are talking and blogging about what will happen to washingtonpost.com and its staff as the new executive editor, Marcus Brauchli, takes the helm in the print newsroom. There’s not much yet. Mediabistro has a memo from WPNI COO Jen Moyer announcing plans to depart on Sept. 1. E&P interviewed Jim Brady; he says he [...]
While marveling at the very idea that 876 people work in editorial at the Los Angeles Times (and catching up on two months of blog reading), I read this: … the question came to mind — if a newsroom, under economic pressure, can afford to lose 10, 20, 30 or even 50 staff positions now, [...]
The World Editors Forum asked five prominent newspaper designers to pick their Top 5 newspaper Web site designs: elpais.com (Spain) guardian.co.uk (Britain) globeandmail.com (Canada) 24sata.hr (Croatia) Times Online (Britain) I agree that elpais.com is No. 1. I wonder what everyone thinks about the rest of these? (Source.) I would add the Las Vegas Sun site [...]
This just came in my e-mail from someone inside the Tampa Tribune: Do you know about the reorganization they’re doing here at the Trib? They herded everyone into a conference room today to tell them about 21 layoffs that will happen tomorrow (effective immediately) and a new reorganization of the newsroom’s hierarchy. [Update: The newspaper [...]
“The New York Times is doing all this video for the Business section. If you never look at their Business section online, you’ll never find it.” My friend Ehrin and I were somewhere in Hanoi, eating pho cuon at a table on the sidewalk, when he told me this. He said the Times has been [...]
From Beet.tv: The reporters in the print newsroom are integrating video shooting into their normal, everyday storytelling, Chet says.
A. Definition of Phosphodiesterase Enzymes
As stated earlier, the average dosage of Uprima® is 2-3mg taken sublingually (dissolved under the tongue) about 15 minutes before sex. (Note that the advent of the sublingual tablet is the only way that apomorphine should be used to treat ED). The drug insert clearly states, that (like most ED drugs), a 3mg dose should not be repeated again within any 8-hour period.
The results may surprise you. Here are a few of the highlights.
CORRESPONDENCE Ivan Borrello: email@example.com
Tadalafil differs from sildenafil and vardenafil in its chemical structure and its lack of inhibition of PDE type 6. Tadalafil exhibits a prolonged half-life of 17.5 hours, and the time to peak concentration is about 2.0 (range 0.5–12.0) hours in healthy volunteers.37 Among men with erectile dysfunction, a significantly higher percentage of attempts at sexual intercourse were successful up to 24–36 hours after use of tadalafil compared with placebo.37,40,41 The pharmacokinetics of tadalafil is not clinically influenced by food or alcohol intake, or by intrinsic factors such as diabetes, or renal or hepatic impairment.41
Table 3. Details of men not included in the study.
Previous studies have suggested a link between heart disease and erectile dysfunction, as the appearance of sexual problems often precedes the development of heart symptoms in men who have type 2 diabetes by approximately three years.
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The most important component of diagnosing erectile dysfunction is obtaining a complete medical and sexual history. It is important to distinguish the condition from other sexual dysfunctions, such as premature ejaculation and loss of libido. Several formalized sexual questionnaires, such as the IIEF (Internation Index of Erectile Function) and EDITS (Erectile Dysfunction Inventory of Treatment Satisfaction), allow one to detect the presence and grade the severity of erectile dysfunction. The complete IIEF is composed of 15 questions; an abridged 5-item version, called the sexual health inventory for men (SHIM), has been developed and validated.29 Allowing a patient to complete such a questionnaire before his first clinical encounter may produce a more comfortable clinical environment.30 The duration of the problem, time of onset and degree of patient and partner concern should also be elucidated. The circumstances surrounding erectile dysfunction may be helpful in determining whether a situational or nonorganic factor is involved. Sudden onset, maintenance of nocturnal erections, presence of psychological problems and concurrent major life events or relationship issues may be associated with nonorganic erectile dysfunction.31 Concurrent medical illnesses and any medications the patient may be taking should be reviewed. Erectile dysfunction is often a component of generalized medical illness and may represent the initial presentation of cardiovascular disease or diabetes. The history may also reveal certain reversible or modifiable risk factors, such as tobacco use or inadequate diabetes control.
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Patients who are refractory to sildenafil may benefit from vardenafil or tadalafil therapy. If none of these is successful, combine the agent with an injection of prostaglandin E-1. Gutierrez et al demonstrated that this combination was more effective than either one alone. Other successful combinations include using a PDE-5 inhibitor with MUSE.5
Have more sex. Men who have sex at least once a week are 50 percent less likely to develop erectile dysfunction. Sex improves cardiovascular health, reduces stress, and may lower your risk of prostate cancer.
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Dr. Bassam Damaj, NexMed's Chief Executive Officer said, "The Notice provides us with a clear pathway to obtaining marketing approval of the product in Canada. The FDA had previously raised most of Health Canada's CMC issues and we were successful in working out a compliance plan with them. We look forward to discussing Health Canada's specific concerns in a face-to face meeting which will be our first since we filed the NDS. In the meantime, we remain optimistic about the approvability of our Vitaros product in Canada."
These devices are generally safe, but hematomas, petechia, and ecchymosis have been reported. Other adverse effects include pain, lower penile temperature, numbness, absent or painful ejaculation, and pulling of scrotal tissue into the cylinder, where it becomes trapped under the ring. Many of these problems can be alleviated by proper selection of the tension rings and cylinders. The devices are very reliable and seem to work better with increased use and practice. They can be operated and used quickly with experience but still tend to be less romantic than other therapeutic options.